Cdc14B and APC/C Tackle DNA Damage
نویسندگان
چکیده
Mitotic exit in budding yeast is regulated by the proteins Cdc14, APC/C(Cdh1), and Plk1. In this issue, Bassermann and colleagues (2008) show that this network of proteins has been rewired in human cells to control the cell cycle in response to DNA damage.
منابع مشابه
The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show that, in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase. This process induce...
متن کاملCdc14b: A New Player in Aging
encodes a dual specificity protein phosphatase essential for mitotic exit. There are two Cdc14 isoforms (a and b) in vertebrates. Cdc14a localizes to the centrosome and Cdc14b localizes to the nucleolus [1]. The two mammalian Cdc14 isoforms have been speculated to exert essential mitotic functions, given the role of budding yeast ScCdc14 played in the cell cycle and the fact that both human CDC...
متن کاملp53 censuses centrosomes
Bleach at the roots of mitotic progression Lim et al. show how hydrogen peroxide at the centrosome spurs cells to advance through mitosis. Cdk1 and regulatory proteins such as cyclin B1, Plk1, and Aurora A cooperate to initiate mitosis. To exit mitosis, cells destroy the regulatory proteins, an effect triggered by the APC/C when it is bound to its coactivator Cdh1. Cdk1 adds phosphates to Cdh1 ...
متن کاملBleach at the roots of mitotic progression
Bleach at the roots of mitotic progression Lim et al. show how hydrogen peroxide at the centrosome spurs cells to advance through mitosis. Cdk1 and regulatory proteins such as cyclin B1, Plk1, and Aurora A cooperate to initiate mitosis. To exit mitosis, cells destroy the regulatory proteins, an effect triggered by the APC/C when it is bound to its coactivator Cdh1. Cdk1 adds phosphates to Cdh1 ...
متن کاملVertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair
A recent study suggested that human Cdc14B phosphatase has a central function in the G2 DNA damage checkpoint. In this study, we show that chicken DT40, human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for the Cdc14A or Cdc14B gene are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. Cdc14A kn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 134 شماره
صفحات -
تاریخ انتشار 2008